-What genes do different phyla share? What genes are unique to different phyla?
-What homologous proteins do different phyla share? What proteins are unique to different phyla?
What biochemical functions do different phyla share? What biochemical functions are unique to different phyla? Does the integration of these biochemical functions vary from phylum to phylum? If two phyla share a function, and the protein that carries out this function in one phylum has a homologue in the other, does the homologues protein carry out the same function?
Research Project Team members areas:
Biology
Statistics
Computer Programming
PhD students:
????????????????????????
The domains appear to have become evolutionary sinks.
They form stable folding patterns.
The domains tend to tolerate amino acid delitions, substitutions, and insertions, thereby making them more likely to survive evolutionary changes.
The domains support essential biological functions.
How do they interact with natural products?
Research Project Team members areas:
Molecular Modeling
Crystallographers
PhD students:
Emma-Karin Millers
Julia
Natural products are biologically validated in structural space.
Natural product combinatorial chemistry have the potential to screen the evolutionary selected space.
Research Project Team members areas:
NMR
Natural Product Chemistry
Medicinal Chemistry
PhD students:
Fredrik Lindahl